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Laboratory assessment including complete blood count, a comprehensive metabolic panel to assess electrolyte status in the setting of significant insensible losses, and baseline arterial blood gas to determine respiratory status are essential on initial evaluation

While challenging the importance of the protein binding hypothesis, it was instead suggested that the key mechanism of cell death involves P450-derived ROS formation during APAP metabolism, which triggers extensive LPO [59, 60]

Oxidized glutathione has already done its job its spent

In addition to their crucial role in plants' antioxidative defence system, GPOX also regulates other critical metabolic processes like root-shoot development, stomatal functioning, regeneration, immune response, photosynthesis and hormonal signalling