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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis (Bays et al., NEJM 2025) reported 28.7% mean weight loss at 68 weeks at the 12 mg dose, plus a 75.8% reduction in WOMAC knee pain scores

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However, there are currently fewer mechanisms for regulating ROS in T cells, so it is still difficult to explain how the altered systemic metabolic environment after obesity affects T cells in the context of the immune response

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