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These neuroprotective effects generalized across GLP-1RAs with variable blood-brain barrier (BBB) permeability (attributable to differences in properties such as molecular size, albumin binding 11 , and potentially receptor-mediated transport into the brain) 12 and diverse experimental conditions 7 , including various rodent species and strains, animal models with or without diabetes mellitus, stroke induction methods, treatment doses and regimens (initiating prior to, during, or even 13 days after stroke induction) 8,13 , indicating a robust class effect

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In contrast, PLMS are noted in a number of other disorders (such as Parkinsons disease and Tourettes syndrome), in association with certain medical conditions (such as pregnancy), in association with other sleep disorders (such as narcolepsy, sleep deprivation, and obstructive sleep apnea (OSA)), as a result of OSA treatment with continuous positive airway pressure), 20 and as a result of certain medications (such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs))

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