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Most semaglutide plateaus last 412 weeks, though individual timelines vary based on genetics, dose, and lifestyle consistency

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Covers Ozempic and Wegovy sales data, STEP trial weight loss outcomes, SELECT cardiovascular results, the oral Wegovy launch, who is using semaglutide in America, and what the latest 2026 research shows

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Dose escalation schedules in GLP-1-based therapies are typically gradual precisely to allow the body to adapt and to minimise GI side effects a principle acknowledged in NICE guidance on approved agents (see NICE TA875)

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