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117 In females with mild-to-moderate chronic constipation, 500 mg magnesium oxide taken three times daily for 28 days significantly improved the frequency of spontaneous bowel movements (SBM), colon transit time, and Bristol stool consistency scores compared with placebo

With the increasing trend of delayed childbearing, the mismatch between declining ovarian function and advanced maternal age is becoming more pronounced, underscoring the urgent need for effective predictive and interventional strategies [9, 10]

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In a recent study, treatment of Diabetes prone BioBreeding rats (BBDP) with FZI/0, an antagonist of the zonulin-mediated disruption of tight junctions, decreased intestinal permeability, and reduced the incidence of diabetes