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These findings suggest that GLP-1 therapies may target both reward-seeking and stress-driven addiction behaviors, but the review emphasized that stress-system effects are complex and not yet fully understood

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In addition, the current review reveals the IGF-1 and GLP-1 activators based on the premise that the restoration of abnormal IGF-1/GLP-1 signaling could result in neuroprotection and neurotrophic effects for the clinical-pathological presentation of ALS and other brain diseases