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10.1016/j.abb.2008.03.008 Arch

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

However, C4 levels in IBS-D are not significantly correlated to mucosal permeability as assessed by urinary excretion of lactulose/mannitol, and in 23 patients with IBS-D, treatment with colesevelam tended to improve stool consistency but did not alter mucosal permeability as assessed by lactulose/mannitol excretion (173)