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It has surprisingly and unexpectedly been found that multiple agent therapy, wherein each agent is independently a sub-therapeutic dose, with either sequential or concurrent administration of the agents, will produce the desired pharmacological response, such as an erection sufficient for sexual intercourse, without producing the frequency or severity of adverse side effects observed at a sufficiently high dose of either agent administered as monotherapy that produces a comparable pharmacological response

These events lead to the release of cellular contents into the surrounding tissues, triggering an inflammatory response [123]

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