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Regional Outlook and Growth Opportunities The market demonstrates strong regional growth dynamics: USA (18.2% CAGR): Leading adoption driven by GLP-1 therapy penetration and product innovation UK (16.4% CAGR): Growth through DTC nutrition brands and functional meal formats Germany (15.8% CAGR): High demand for premium, structured nutrition solutions Japan (15.1% CAGR): Convenience-led, portion-controlled innovation South Korea (14.7% CAGR): Growth in functional beverages and snack formats North America leads commercialization, while Europe and East Asia drive premiumization and format innovation

[11] Renal function should be checked if dehydration is suspected

Circ Res 2021, 128(1): 136-149