The FDA in the United States has issued warnings about contamination and dosing inconsistencies in compounded GLP-1 products, and Health Canada has echoed similar concerns

There are certain groups of people who should not follow a keto diet, including people who: are pregnant or lactating take certain medications, such as SGLT-2 inhibitors have any of the following conditions: a history or current diagnosis of an eating disorder kidney disease pancreatitis liver failure disorders of fat metabolism In some people, the keto diet could potentially lead to various benefits, including: weight loss, if a person could benefit from losing weight a reduced dependency on antidiabetic medication lower blood pressure improved insulin sensitivity increased levels of high-density lipoprotein (HDL) cholesterol, without increasing low-density lipoprotein (LDL) cholesterol reduction in triglycerides improved quality of life As keto diets may help reduce blood sugar levels and weight, if needed, people with type 2 diabetes who follow a keto diet may be able to reduce their need to take antidiabetic medication

In a Canadian study, Hg was detected in all samples of swordfish, tuna, marlin, and shark purchased from major supermarket outlets and fish retailers, with swordfish containing the greatest concentration (57)
Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist, a novel class of medication that targets both GIP and GLP-1 receptors to enhance insulin secretion, suppress glucagon release, and slow gastric emptying