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Harno E, Cottrell EC, Yu A et al (2013) 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitors still improve metabolic phenotype in male 11beta-HSD1 knockout mice suggesting off-target mechanisms

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Clinical trials have shown that canagliflozin reduces major adverse cardiovascular events (MACE) [15], while empagliflozin decreases cardiovascular mortality by 38% and heart failure hospitalizations by 32% in patients with T2DM at high cardiovascular risk [16]