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[7] [8] By activating all three receptors, retatrutide is hypothesised based largely on preclinical and early-phase human data to produce complementary effects on appetite suppression, energy expenditure, and glucose metabolism

Studies such as the SUSTAIN and STEP trials have demonstrated their benefits in both glycemic control and weight reduction, positioning GLP-1 agonists as cornerstones in the treatment of metabolic disorders

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[DOI] [PubMed] [Google Scholar] 69.Wilding J.P.H., Batterham R.L., Calanna S., Davies M., Van Gaal L.F., Lingvay I., McGowan B.M., Rosenstock J., Tran M.T.D., Wadden T.A., et al