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The obtained nano-Pt/VP@MLipo that could convert H 2 O 2 into O 2 for enhanced PDT and chemotherapy inhibited the aggressive 4T1 tumor growth and the lung metastasis, and prolonged animal survival rate without leading to overt toxicity ( Therefore, the recent revolution in tumor-targeting Pt nanosystems, including Pt-incorporated/conjugated nanosystems, Pt prodrugs, and Pt inorganic NPs, provides many opportunities to improve the tumor-targeting efficiency of Pt drugs and meanwhile decreased the indiscriminate toxicity to normal tissues, especially peripheral nervous systems

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