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Selpercatinib and pralsetinib have shown remarkable efficacy, including a few complete responses and favorable safety in phase 1/2 trials

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Liquid chromatography-mass spectrometry was performed using a Waters Acquity Premier UPLC system coupled to a SELECT SERIES Cyclic IMS, which combines a Q-Tof (Quadrupole-Time of Flight) mass spectrometer with cIM (Cyclic Ion Mobility) (Waters, Milford, MA), operated in positive electrospray ionization mode