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However, covalent modification of the 20S proteasome by MG reduces its degradation activity, leading to persistent activation of the unfolded protein response (UPR), which ultimately triggers apoptosis and inflammatory responses (129, 130)

Additionally, the adoption of standardized DOR models would facilitate more consistent and reproducible evaluations across studies

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Its mechanism involves high-affinity binding to Fe 3+ to form stable ferrioxamine complexes, which are subsequently eliminated from the body