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The authors concluded: The use of GLP-1 agonists should be considered in T1DM patients who are overweight or obese and not at glycemic goals despite aggressive insulin therapy. After conducting clinical trials with a GLP-1 agonist, Novo Nordisk decided not to pursue FDA approval for treating type 1 diabetes

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Together, these effects have been documented in experimental systems to modify gene expression patterns in ways that reduce chronic inflammatory signaling and support transitions toward tissue stabilization