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Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway

In controlled clinical trials, daily intakes of aged garlic extract at doses between 1.2 g-2.4 g (containing 1.2 to 2.4 mg of S-allyl-L-cysteine) consistently resulted in reductions in SBP by 9 mm Hg-10 mm Hg and reductions in DBP by 4 mm Hg-8 mm Hg in a majority of patients with uncontrolled hypertension (110, 143)

By restricting mPTP opening, these agents reduce mitochondrial swelling and rupture, thereby limiting the release of DAMPs, including mtDNA

Novel therapies with precision mechanisms for type 2 diabetes mellitus