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Summary Keywords allergic asthma, immunometabolism, innate immunity, innate lymphoid Cells (ILC2), pentose phosphate pathway, redox homeostasis and signaling, respiratory immunology Citation Cain J, Hurrell BP, Shen S, Speliakos P and Akbari O (2026) Melatonin suppresses ILC2-driven airway hyperreactivity via glutathione-dependent metabolic reprogramming

Headaches Mild headaches can occur, often linked to dehydration or metabolic changes

aspartate transferase, ALP

Briefly, at the cellular level, CS temperature induces changes in membrane composition and fluidity by the enhanced activity of phospholipases (PLs) and lipoxygenases (LOXs), the main enzymes responsible for the hydrolysis of phospholipids (Aghdam et al., 2014)