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Z-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH 2 2CF 3 COOH ( 12 ) Linear hexapeptide 11 (300 mg, 0.197 mmol) was dissolved in DMF (30 mL), then HOBtH 2 O (51 mg, 0.3305 mmol), NMM (65 L), and DCC (68 mg, 0.3305 mmol) were added, and the mixture was stirred at r.t

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Research demonstrates that TB-500 forms functional complexes with PINCH-1 and integrin-linked kinase (ILK) that can inhibit TNF--induced NF-B activation through blocking RelA/p65 translocation, providing rapid suppression of inflammatory transcriptional programs