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In vivo , FTO knockdown significantly elevates YTHDF2 expression in the striatum of PD mice, inhibits m 6 A demethylation of BAP1 and reduces BAP1 expression, upregulates SLC7A11 expression, decreases -Syn, MDA, Fe 2+ , and 4-HNE levels, suppresses neuronal ferroptosis and disruptions in the amino acid antioxidant system, and promotes dopaminergic neuronal survival in PD mice (Li et al., 2025c)
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Cai S, Khoo J, Channon KM (2005) Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells
Interestingly, the effects of folate deficiency regulate miRNA differently in cancer cells vs
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