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3.4 Glucoselipid metabolism and IR Insulin resistance serves as the crucial hub connecting metabolic derangements and reproductive dysfunction in PCOS, making it a primary target for GLP-1RA intervention within the metabolicreproductive axis

This is the most speculative of the three pathways - direct human evidence is limited - but it is the rationale most often given for pairing MOTS-c with retatrutide specifically rather than with a slower-deficit compound

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GLP-1s have a plethora of benefits ranging from reducing inflammation, to stimulating the immune system, to reducing oxidative stress, to boosting mitochondrial function, that lead to documented neurocognitive and cardiovascular protection