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Many of these examples are the result of gene duplications followed by neofunctionalization by a single key amino acid mutation, resulting in a novel substrate specificity and recruitment to a different metabolic pathway (Leong and Last, 2017)

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Vascular endothelial activation was confirmed by an increased abundance of circulating P-selectin and vascular endothelial adhesion molecule 1 (VCAM-1) in the AF group