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Pergolizzi explains why and what you can do to reduce your pain and keep your heart healthy

Risks of Staying in a Calorie Deficit for Too Long Prolonged calorie restriction risks nutritional deficiencies, bone loss, metabolic adaptation, weight cycling, and an association with disordered eating behaviours including binge eating disorder and anorexia nervosa

Recommended articles Clinical Impact of Semaglutide, a Glucagon-Like Peptide-1 Receptor Agonist, on Obesity Management: A Review Alorfi NM, Algarni AS Clinical Pharmacology: Advances and Applications 2022, 14:61-67 Published Date: 3 August 2022 Semaglutide 2.4 Mg for the Management of Overweight and Obesity: Systematic Literature Review and Meta-Analysis Smith I, Hardy E, Mitchell S, Batson S Diabetes, Metabolic Syndrome and Obesity 2022, 15:3961-3987 Published Date: 17 December 2022 Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations Chao AM, Tronieri JS, Amaro A, Wadden TA Drug Design, Development and Therapy 2022, 16:4449-4461 Published Date: 29 December 2022 Novel Anti-obesity Therapies and their Different Effects and Safety Profiles: A Critical Overview Telci Caklili O, Cesur M, Mikhailidis DP, Rizzo M Diabetes, Metabolic Syndrome and Obesity 2023, 16:1767-1774 Published Date: 14 June 2023 GLP-1RA Liraglutide and Semaglutide Improves Obesity-Induced Muscle Atrophy via SIRT1 Pathway Xiang J, Qin L, Zhong J, Xia N, Liang Y Diabetes, Metabolic Syndrome and Obesity 2023, 16:2433-2446 Published Date: 15 August 2023

The report, published on Monday in Nature Medicine, describes the effect of tirzepatide on a single individual, and the findings cannot be generalized to others, the researchers cautioned