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Conclusion and perspectives In summary, we begin with the key role of changes in synaptic plasticity in sustained antidepressant effect, focus on synaptic plasticity, and followed by a discussion of the modulation of synaptic plasticity by neurexins to demonstrate the potential and feasibility of studies of sustained antidepressant effect through the modulation of synaptic plasticity by neurexins

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Subgroup analyses by drug type, duration of treatment, and patient characteristics similarly showed no concerning signals