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These medications may interact with nitrates, certain blood pressure medications, alpha-blockers, alcohol, and other PDE-5 therapies - and some of those interactions can cause significant drops in blood pressure

Variations in study designs, follow-up durations, and outcome definitions add complexity, particularly given the low certainty of evidence for most comparisons

In other words, while weight-loss medications can help you look fitter on the outside, they may actually decrease your physical fitness in certain key areas

Clinical research priorities include properly designed human clinical trials with adequate sample sizes, appropriate controls, and validated outcome measures