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Description

In vitro studies confirm that linagliptin suppresses the proliferation of several tumor cell lines, including colorectal cancer HCT116, breast cancer MCF-7, and liver cancer HepG2, via mechanisms that involve cell cycle arrest and apoptosis induction [96]

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Unlike many peptide ligands that possess well-characterized receptor targets and signaling pathways, DSIP remains associated with an incompletely defined mechanism of action