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The symptoms of vitamin B12 deficiency can be quite debilitating and include, according to scientific research: Chronic fatigue and weakness Shortness of breath Heart palpitations Tingling or numbness in the extremities Poor balance Loss of concentration and poor memory Disorientation Mood changes, including depression Insomnia Imagine trying to maintain a healthy, active lifestyle when you're constantly battling severe fatigue and low energy

doi: 10.1006/pupt.2001.0306

C., Zhu, M

Clearly, species of interest will influence which neuropeptides can be readily studied, as the tools, models, and neuropeptides available vary according to species