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The 1000mg dose seems perfect not too harsh but definitely effective

Statistical significance was determined by One-Way ANOVA followed by Dunnett multiple comparison test ( b and c ) and Two-Way ANOVA with dk multiple comparison test ( e and f ), with significance indicated by asterisks (*P 0.9999 for V214A in panel b (amplitude)

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Curr Biol 10 , 293300 (2000)