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Immune and Recovery Modulation Studies: In sleep-deprived rats and limited clinical observations, DSIP exhibited mild anti-inflammatory effects (reduced IL-6, TNF-), enhanced antioxidant enzyme activity (SOD, catalase), and accelerated physiological recovery from physical/psychological stress

4.2 Regulation of ferroptosis by inflammatory cytokines and immune signaling 4.2.1 Classic proinflammatory cytokines IL-1 can induce the synthesis of matrix-degrading enzymes MMP-13 and ADAMTS-5 by chondrocytes and synovial cells (117)