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In view of the role of Se deficiency in promoting thyroid tumorigenesis and progression, appropriate Se supplementation for differentiated thyroid cancer has been proposed to delay the disease progression and improve the prognosis (98).Kato, M

129 Preclinical studies in various PD animal models indicate that GLP-1RAs such as liraglutide, semaglutide, and lixisenatide promote dopamine synthesis and elevate striatal dopamine levels, thereby conferring neuroprotection to dopaminergic neurons

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In experimental models, GLP-1 receptor activation stimulates cyclic AMP (cAMP) production and activates protein kinase A (PKA), which subsequently influences gene transcription and cellular metabolism