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The levels of CREB gene expression in the brain of untreated Pla2g6 / mice at the humane end-point were found to be significantly lower than those in age-matched wild-type controls (Fig

[23] Instead, alteration of the profile of the other lipid subtypes present in the liver, such as diacylglycerols, phospholipids, ceramides, and free cholesterol, has a more significant role in the pathogenesis of MASLD

Examining the downstream mechanisms through which MC1R-cAMP signalling antagonises inflammatory cytokine production and studying how MT-1s anti-inflammatory effects in skin cells contribute to its photoprotective biology beyond melanin-dependent UV absorption