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However, results can vary depending on the individual

Additional processes, including mitochondrial dysfunction and inflammasome activation, can further amplify oxidative stress and inflammation 47

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The researchers used a powerful molecule called bone morphogenetic protein 2 (BMP2) to initiate bone formation after microfracture, but then stopped the process midway with a molecule that blocked another signaling molecule important in bone formation, called vascular endothelial growth factor (VEGF)