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Besides improving glucose control, reducing body weight, and lowering arterial blood pressure (surrogate endpoints), the breakthroughs were the demonstration of a significant reduction in cardiovascular and renal events in patients with type 2 diabetes at high risk

PlexusDx Precision Peptide Genetic Test ($99 add-on) can reveal these variants, supporting more informed provider conversations, though genetic predisposition does not guarantee outcomes

While these medications operate slightly differently, they both target appetite and craving control by interacting with specific brain receptors

Exedin-4, a naturally occurring GLP-1RA derived from Gila monster venom, has also been shown to suppress macrophage-driven inflammation by enhancing adiponectin expression