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Mytho -KO + M3 ( n = 48), Mytho -KO + M5 ( n = 40), Mytho -KO + M3/M5 ( n = 53) (1-way ANOVA with Tukeys multiple-comparison test)

NAD+ also has a broader longevity application because sirtuin activation is one of the most studied anti-aging mechanisms at the cellular level

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Since liraglutide is not metabolized or eliminated by the kidneys or liver, its pharmacokinetics are not significantly affected by renal or hepatic dysfunction, providing a potential treatment advantage in patients with type 2 diabetes and concomitant kidney/liver disease [59]