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They are also present in various brain regions, including areas involved in mood regulation, reward processing, and emotional behaviour

More serious but less common adverse effects observed in trials or associated with this drug class include: Increased heart rate , a class effect seen with GLP-1 receptor agonists [15] [12] Gallbladder disease , including gallstones (cholelithiasis), which has been associated with rapid weight loss and incretin-based therapies more broadly

The future may involve: Sequencing and Combination: Using agents with complementary mechanisms (e.g., an incretin for weight loss combined with a myostatin inhibitor for lean mass preservation)