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Research indicates that even modest weight reduction of 5-10% of body weight can significantly improve reproductive hormone profiles, including reductions in insulin resistance, androgens, and improvements in sex hormone-binding globulin levels

TRIUMPH-4 represents Eli Lilly's first successful Phase 3 trial for Retatrutide, moving beyond the promising Phase 2 results from 2023 that showed 24% weight loss

The studys data does not follow patients long enough to say what the muscle loss means over a decade of use

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