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Translational studies using exosomes showed a relationship between the epigenetic modulation of glutamatergic function and a brain metabolic dysfunction known as insulin resistance (IR) as showed by an increase and sex-specific phosphorylation in the expression of IRS1, a key marker of the insulin signaling cascade, in discrete exosomes enriched for the neural cell adhesion molecule L1 (L1CAM), a protein highly expressed in the brain [52, 70,71,72]

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GPX1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 223 amino acids and molecular mass of 24.2kDa

Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment