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Notably, weight-specific patterns emerged in serious adverse events: papillary thyroid carcinoma demonstrated significantly higher incidence in the high-weight cohort compared to other groups (p 360 days)

In the absence of published reports describing synchronized weight loss and CRC management in patients with severe obesity, three novel retrospective case examples were included to demonstrate feasibility during neoadjuvant treatment, with institutional review board approval obtained for all cases

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The FDA logged 605 adverse event reports specifically tied to compounded semaglutide as of mid-2025, and GLP-1 medication-error reports exceeded 25,000 in 2025