Therefore, it is hypothesized that glutathione interferes with the synthesis and catabolism of the differential metabolite arginine through significant down-regulation of the D-Amino acid metabolism pathway and up-regulation of the Necroptosis metabolism pathway, thus further affecting the production and metabolism of urea to exert a protective effect against liver injury in bullfrogs
Nonalcoholic fatty liver disease (NAFLD) Affecting more than 30% of people worldwide, NAFLD is caused by the build-up of lipids within hepatic cells and has been linked to obesity, type 2 diabetes, and hyperlipidemia
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Researchers use in-vitro models of pulmonary fibrosis to study this process, often by treating lung fibroblast cell lines (e.g., MRC-5) with the pro-fibrotic cytokine TGF-1
