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And insulin resistance is not a small side plot

L-Carnitine helps cells create energy more efficiently

The core machinery of this axis is the IP3R-GRP75-VDAC1 tripartite complex, where GRP75 (Szabadkai et al., 2006) acts as a linker protein that physically bridges the IP3R on the ER (Rapizzi et al., 2002), funneling ions directly into the mitochondrial matrix (Szabadkai et al., 2006)

These are signals, not conclusions but theyre coming directly from patients, unprompted, and thats worth paying attention to, says the first author, Neil Sehgal, a doctoral student at the University of Pennsylvania in Philadelphia