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Similarly, the binding site of citalopram (Figure 3, left panel, bottom row) is composed of hydrophobic, polar, and charged residues

Inhibition of system Xc- led to the depletion of cysteine, lacking GSH synthetic substrate, and then impaired the function of antioxidant enzyme GPX4 (Yang et al., 2014), which finally caused an imbalance of homeostatic oxygen homeostasis, leading to ferroptosis ( via CRISPR-Cas9 proved that the cystine/glutamate exchanger xCT is essential for amino acid and redox homeostasis in the ferroptosis process (Jiang et al., 2015

Kidney and liver function can deteriorate if overdose-induced dehydration persists unchecked