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Trial SELECT (Lincoff et al., NEJM 2023) Design Phase 3 / 39.8 mo mean follow-up Population 17,604 adults with CVD + overweight or obesity, no diabetes Key result 20% reduction in major heart events (HR 0.80

The main scenario (EL2) was developed to mirror the core components in the 2025 EAT Lancet reportshift to a healthy reference diet, increased agricultural productivity and a reduction in FLW, with the BAU scenario as a counterfactual to EL2

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