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Its one of the core symptoms of depression but can appear on its own, especially in response to changes in brain chemistry

La contraindicacin ms importante es la historia personal o familiar de carcinoma medular de tiroides (CMT) o el diagnstico de neoplasia endocrina mltiple tipo 2 (NEM-2) , un sndrome hereditario que aumenta el riesgo de varios tumores endocrinos, incluyendo CMT

doi: 10.3389/fphys.2026.1764165 Received 15 January 2026 Revised 29 December 2025 Accepted 19 January 2026 Published 09 February 2026 Volume 17 - 2026 Edited by Khosrow Kashfi, City University of New York, United States Reviewed by Jerzy Beltowski, Medical University of Lublin, Poland John Toscano, Johns Hopkins University, United States Updates Copyright 2026 Hirabayashi, Sasaki, Ohno, Takayama, Yamada and Hanaoka

Common side effects are gastrointestinal (nausea, diarrhoea, vomiting), whilst serious adverse effects include pancreatitis, diabetic retinopathy complications, and acute kidney injury