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During an average follow-up of 26.3 months (2.2 years, SD 1.9 years), the annual rate of acute healthcare utilization was 1.52 visits/year in the GLP1-RA group and 1.67 visits/year within the DPP4i group (coefficient of regression = 0.15, 95% CI 0.25 to 0.05, p = 0.004)

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In contrast to HO-1, the HO-2 isozyme is constitutively expressed, highly detectable in brain, testis, endothelial and smooth muscle cells from cerebral vessels