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The results showed no significant differences in any of the indicators, indicating that FOXO4-DRI treatment did not adversely affect liver or kidney function or cell viability in mice (Supplementary Figures S2AC)

Secondary outcome measurements included reduction in body weight from baseline by at least 5% or 10% by week 26, changes in waist circumference, total cholesterol, HDL, LDL, VLDL, and triglycerides, and levels of different glycemic variables including HbA1C, fasting plasma glucose, fasting insulin, insulin resistance, and the functioning of beta-cells

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The Arabidopsis KH-domain RNA-binding protein ESR1 functions in components of jasmonate signalling, unlinking growth restraint and resistance to stress