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"It varies patient to patient, but fat intake and alcohol intake may prompt or worsen existing nausea, vomiting, heartburn or reflux symptoms because of this," explains Todd Worley, M.D., FACS, an obesity medicine specialist and bariatric surgeon at Houston Methodist Hospital in Texas, who commonly prescribes both Ozempic and Wegovy

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In conclusion, the BP lowering effect of DPP-4i may be reduced by stimulating sympathetic activity via reducing degradation of GLP-1 and substance P when combined with ACEI, especially in high-dose ACEI