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NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition

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For example, in a 68-week clinical trial, semaglutide users experienced an average weight loss of 15.8%, with 86% of participants achieving clinically meaningful results

Interestingly, induction of c-MET phosphorylation was observed upon the blockade of PI3K/AKT signaling, confirming a negative control of c-MET activity by AKT and warranting clinical investigation to determine the significance of p-c-MET as an escape mechanism to AKT inhibitors (Fig