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Finally, because of the varied locations and antioxidant capacities of different antioxidants, it is clear that consumption of a single antioxidant in the diet (e.g., vitamin C) is not sufficient to provide optimal protection from radical-mediated damage in cells

The "two-hit theory" proposed that the initial metabolic disruptions, such as insulin resistance (IR), hyperglycemia, and triglyceride formation in hepatocytes, constitute the first hit, resulting in hepatic steatosis

Kainate receptor channel opening and gating mechanism