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A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)

Vegan and vegetarian women receive little or no vitamin B12 in their diets

Smith realizes that although both sterilized and bacteriostatic waters can be used for reconstitution purposes, bacteriostatic water would be the better choice for his clinical trial preparation due to its longer shelf life and preservative properties

B12 injections are most appropriate for people with confirmed or suspected B12 deficiency