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The FDA-approved iron supplement ferumoxytol (an iron oxide nanoparticle) has been shown to inhibit subcutaneous adenocarcinoma development in mice by promoting TAM polarization toward the M1 phenotype and preventing hepatic tumor metastasis

Therapeutic peptides & receptor desensitization: Rahman, Lee & Seeds, Therapeutic Peptides in Orthopaedics, JAAOS Global Research & Reviews , 2026 JAAOS Global

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MUT MUT (methylmalonyl-CoA mutase) is a mitochondrial enzyme that converts methylmalonyl-CoA (from the earlier synthesised alpha ketobutyrate) to succinyl-CoA with adenosyl-cobalamin as a cofactor